Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 9/20 | 0.57 |
| ▸ | MMP2 | P08253 | 4/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671594 | 0.88 | MMP2 (0.68) | MMP9MMP2CA1CA2 | |
| SCHEMBL7671733 | 0.82 | MMP9 (0.57) | MMP9MMP2CTSL | |
| SCHEMBL7665147 | 0.82 | MMP9 (0.71) | MMP9MMP2CTSL | |
| SCHEMBL7663396 | 0.82 | MMP9 (0.71) | MMP9MMP2CTSL | |
| SCHEMBL7673655 | 0.80 | MMP9 (0.78) | MMP9MMP2 | |
| SCHEMBL7667544 | 0.80 | MMP9 (0.78) | MMP9MMP2 | |
| SCHEMBL9554556 | 0.75 | MME (0.52) | LTA4HMMEECE1S1PR1 | |
| SCHEMBL7583642 | 0.75 | MMP9 (0.70) | MMP9MMP2 | |
| SCHEMBL28366545 | 0.74 | MME (0.61) | MMEECE1 | |
| SCHEMBL14191412 | 0.74 | MMP9 (0.74) | MMP9MMP2CA1CA2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |