Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.56 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.56 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403631 | 0.83 | GABRG2 (0.40) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2461273 | 0.83 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL12068741 | 0.76 | GABRA1 (0.64) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7208591 | 0.73 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7672131 | 0.73 | GABRG2 (0.68) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7665902 | 0.72 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL19575097 | 0.72 | GABRG2 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7671983 | 0.72 | GABRG2 (0.70) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL15386010 | 0.72 | GABRG2 (0.75) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7667586 | 0.72 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355638-B1 | COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. (GB) | 2002-03-12 | — | — | US | claimed |
| US-6355638-B1 | COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. (GB) | 2002-03-12 | — | — | US | disclosed |