Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666120 | 0.91 | PDGFRA (0.49) | SHMT2PDGFRACCNE1CDK2MKNK2 | |
| SCHEMBL7672785 | 0.89 | PDGFRA (0.48) | SHMT2PDGFRACCNE1CDK2MKNK2 | |
| SCHEMBL7672786 | 0.86 | PDGFRA (0.46) | SHMT2PDGFRACCNE1CDK2MKNK2 | |
| SCHEMBL7671191 | 0.83 | GBA1 (0.48) | PDGFRACCNE1CDK2NPC1RAB9A | |
| SCHEMBL7363934 | 0.83 | CCNE1 (0.52) | PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7666083 | 0.79 | PDGFRA (0.42) | PDGFRACCNE1CDK2PTK2CTSL | |
| SCHEMBL7672318 | 0.79 | PDE1A (0.43) | PDGFRACCNE1CDK2GAAMAPK1 | |
| SCHEMBL7663415 | 0.79 | PDGFRA (0.47) | PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7362489 | 0.79 | CCNE1 (0.49) | PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7675152 | 0.77 | PDGFRA (0.43) | PDGFRACCNE1CDK2GAACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |