Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672318 | 0.94 | PDE1A (0.43) | GBA1ALDH1A1KDM4ESMN1; SMN2PDGFRA | |
| SCHEMBL7675152 | 0.89 | PDGFRA (0.43) | PDGFRACCNE1CDK2CTSLTMIGD3 | |
| SCHEMBL7666120 | 0.88 | PDGFRA (0.49) | ALDH1A1MAPTSMN1; SMN2PDGFRACCNE1 | |
| SCHEMBL7661515 | 0.87 | CCNE1 (0.54) | PDGFRACCNE1CDK2CTSLTMIGD3 | |
| SCHEMBL7666144 | 0.83 | CDK4 (0.45) | ALDH1A1MAPTKDM4EKMT2APDGFRA | |
| SCHEMBL7672171 | 0.83 | SHMT2 (0.46) | MAPTSMN1; SMN2PDGFRACCNE1CDK2 | |
| SCHEMBL7358873 | 0.83 | CTSL (0.46) | PDGFRACCNE1CDK2CTSL | |
| SCHEMBL7672863 | 0.83 | PDGFRA (0.52) | PDGFRACCNE1CDK2TMIGD3ADORA2A | |
| SCHEMBL7672785 | 0.82 | PDGFRA (0.48) | ALDH1A1MAPTSMN1; SMN2PDGFRACCNE1 | |
| SCHEMBL7674300 | 0.81 | CTSL (0.50) | PDGFRACCNE1CDK2CTSLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |