Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672785 | 0.94 | PDGFRA (0.48) | PDGFRACCNE1CDK2GAAMAPT | |
| SCHEMBL7672786 | 0.92 | PDGFRA (0.46) | PDGFRACCNE1CDK2GAAMAPT | |
| SCHEMBL7672171 | 0.91 | SHMT2 (0.46) | PDGFRACCNE1CDK2GAAMAPT | |
| SCHEMBL7671191 | 0.88 | GBA1 (0.48) | PDGFRACCNE1CDK2MAPTCTSL | |
| SCHEMBL7674300 | 0.84 | CTSL (0.50) | PDGFRACCNE1CDK2CTSLNPC1 | |
| SCHEMBL7672318 | 0.84 | PDE1A (0.43) | PDGFRACCNE1CDK2GAAMAPK1 | |
| SCHEMBL7666144 | 0.82 | CDK4 (0.45) | PDGFRACCNE1CDK2GAAMAPT | |
| SCHEMBL7675152 | 0.81 | PDGFRA (0.43) | PDGFRACCNE1CDK2GAACTSL | |
| SCHEMBL7673595 | 0.81 | KDM4E (0.45) | PDGFRACCNE1CDK2MAPTMAPK1 | |
| SCHEMBL7672132 | 0.79 | GALR2 (0.44) | PDGFRACCNE1CDK2MAPTCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |