Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754861 | 0.76 | P2RY1 (0.45) | HTTLMNA | |
| SCHEMBL316115 | 0.74 | LTA4H (0.42) | ALDH1A1HTTLMNAKMT2ANPC1 | |
| SCHEMBL217907 | 0.74 | RAB9A (0.42) | ALDH1A1HTTKMT2ANPC1RAB9A | |
| SCHEMBL1345301 | 0.71 | HPGD (0.41) | ALDH1A1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9499646 | 0.71 | HPGD (0.41) | ALDH1A1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29539584 | 0.71 | KDM4E (0.56) | ALDH1A1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18984732 | 0.71 | KDM4E (0.56) | ALDH1A1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11543918 | 0.71 | SLC6A2 (0.47) | ALDH1A1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL314481 | 0.70 | KMT2A (0.39) | ALDH1A1HTTLMNAKMT2ARAB9A | |
| SCHEMBL1436765 | 0.70 | HPGD (0.59) | ALDH1A1HTTSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458813-B1 | 2-CYCLOHEXYLOXY-5-(2-CHLOROPHENYLCARBONYLAMINO)PYRIDINE, FOR EXAMPLE; TREATING INFLAMMATION, PAIN, DIABETES, CANCER | AMGEN INC. | 2002-10-01 | — | — | US | disclosed |