Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679625 | 1.00 | HRH3 (0.39) | HRH3KDM4ETSHRALDH1A1GLA | |
| SCHEMBL7680859 | 0.86 | HTR2C (0.38) | TLR7 | |
| SCHEMBL7679628 | 0.86 | MC4R (0.37) | KDM4EGAAHRH4CHKACHIA | |
| SCHEMBL27501203 | 0.85 | CHIA (0.35) | HRH3KDM4EALDH1A1GAAHRH4 | |
| SCHEMBL7681799 | 0.84 | JAK3 (0.37) | KDM4ETSHRALDH1A1GAACHKA | |
| SCHEMBL27471040 | 0.83 | PDE10A (0.39) | HRH3 | |
| SCHEMBL27471926 | 0.81 | KHK (0.41) | ALDH1A1 | |
| SCHEMBL7679970 | 0.78 | MC4R (0.42) | HRH3KDM4EALDH1A1HRH4CHKA | |
| SCHEMBL7681200 | 0.76 | KDM4E (0.32) | KDM4ELMNAMC4R | |
| SCHEMBL7673338 | 0.73 | HRH3 (0.40) | HRH3CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |