Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673262 | 0.72 | — | — | |
| SCHEMBL5736771 | 0.71 | CYP2A6 (0.32) | — | |
| SCHEMBL15952484 | 0.71 | ESR1 (0.40) | CYP4F2CYP4A11 | |
| SCHEMBL24380347 | 0.70 | OPRM1 (0.42) | — | |
| SCHEMBL18326533 | 0.66 | IDO1 (0.45) | — | |
| SCHEMBL7981188 | 0.65 | ESR2 (0.30) | — | |
| SCHEMBL21725626 | 0.64 | OPRM1 (0.40) | — | |
| SCHEMBL24602755 | 0.63 | CYP1A2 (0.52) | KCNH2 | |
| SCHEMBL17722492 | 0.63 | LPL (0.46) | — | |
| SCHEMBL13923732 | 0.62 | ESR1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495552-B2 | TREATMENT OR PREVENTION OF THE DISEASES AND CONDITIONS WHICH RESPOND TO TREATMENT BY RETINOIDS AND OR WHICH IN HEALTHY MAMMALS, INCLUDING HUMANS, ARE CONTROLLED BY NATURAL RETINOIC ACID. | ALLERGAN, INC. | 2002-12-17 | — | — | US | disclosed |