Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678718 | 0.83 | CYP1A2 (0.37) | SMN1; SMN2CYP1A2HRH4 | |
| SCHEMBL7676302 | 0.81 | P2RX7 (0.33) | RAB9ASMN1; SMN2 | |
| SCHEMBL7682669 | 0.81 | TRPV1 (0.36) | RAB9ACYP1A2 | |
| SCHEMBL7681496 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP1A2HRH4 | |
| SCHEMBL7676533 | 0.72 | HRH4 (0.36) | SMN1; SMN2HRH4 | |
| SCHEMBL7680475 | 0.69 | HRH4 (0.36) | HRH4 | |
| SCHEMBL7824628 | 0.69 | P2RX7 (0.33) | HRH4 | |
| SCHEMBL7818712 | 0.69 | HRH4 (0.35) | HRH4 | |
| SCHEMBL27434416 | 0.68 | CYP1A2 (0.35) | CYP1A2 | |
| SCHEMBL7473964 | 0.68 | HRH4 (0.39) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |
| EP-0885212-A1 | QUINOXALINEDIONES | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032873-A1 | QUINOXALINEDIONES | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-09-12 | — | — | WO | disclosed |