Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678718 | 0.84 | CYP1A2 (0.37) | KMT2AALDH1A1HSD11B1CYP1A2 | |
| SCHEMBL7673287 | 0.81 | RAB9A (0.49) | RAB9ACYP1A2 | |
| SCHEMBL7681496 | 0.78 | SMN1; SMN2 (0.43) | CYP1A2 | |
| SCHEMBL7676242 | 0.74 | GRIN1 (0.39) | — | |
| SCHEMBL7676533 | 0.70 | HRH4 (0.36) | — | |
| SCHEMBL7824628 | 0.70 | P2RX7 (0.33) | — | |
| SCHEMBL27434416 | 0.69 | CYP1A2 (0.35) | KMT2AMAPTALDH1A1HSD11B1CYP1A2 | |
| SCHEMBL8947264 | 0.69 | P2RX7 (0.49) | TRPV1KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL8947317 | 0.68 | ALDH1A1 (0.57) | TRPV1KMT2AKDM4EMAPK1TSHR | |
| SCHEMBL8947311 | 0.68 | ALDH1A1 (0.57) | TRPV1KDM4EMAPK1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |
| EP-0885212-A1 | QUINOXALINEDIONES | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032873-A1 | QUINOXALINEDIONES | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-09-12 | — | — | WO | disclosed |