Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.32 |
| ▸ | CBLB | Q13191 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824628 | 0.83 | P2RX7 (0.33) | HRH4P2RX7 | |
| SCHEMBL7681496 | 0.83 | SMN1; SMN2 (0.43) | HRH4SMN1; SMN2 | |
| SCHEMBL7676302 | 0.80 | P2RX7 (0.33) | SMN1; SMN2P2RX7 | |
| SCHEMBL7680475 | 0.77 | HRH4 (0.36) | HRH4BDKRB2 | |
| SCHEMBL7676249 | 0.75 | HRH4 (0.36) | HRH4 | |
| SCHEMBL7678718 | 0.75 | CYP1A2 (0.37) | HRH4SMN1; SMN2 | |
| SCHEMBL7682970 | 0.74 | HRH4 (0.33) | HRH4 | |
| SCHEMBL7473964 | 0.73 | HRH4 (0.39) | HRH4 | |
| SCHEMBL7673287 | 0.72 | RAB9A (0.49) | HRH4SMN1; SMN2 | |
| SCHEMBL7676130 | 0.70 | MAPT (0.40) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |