Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27712072 | 0.98 | KCNH2 (0.33) | KCNH2ALDH1A1CCKBRMTNR1AMTNR1B | |
| Methylamine SCHEMBL28799881 | 0.95 | MTNR1A (0.33) | KCNH2ALDH1A1CCKBRMTNR1AMTNR1B | |
| SCHEMBL21494400 | 0.82 | F12 (0.36) | — | |
| SCHEMBL29557640 | 0.81 | HPGD (0.33) | KCNH2ALDH1A1CCKBRMTNR1AMTNR1B | |
| SCHEMBL22864722 | 0.81 | HPGD (0.33) | KCNH2ALDH1A1CCKBRMTNR1AMTNR1B | |
| SCHEMBL3139041 | 0.81 | CA1 (0.33) | KCNH2ALDH1A1CCKBRCHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL27907053 | 0.80 | CA1 (0.33) | KCNH2ALDH1A1CCKBRCHRNB4CHRNA3 | |
| SCHEMBL27582656 | 0.74 | CHRNB4 (0.37) | KCNH2ALDH1A1CCKBRMTNR1AMTNR1B | |
| SCHEMBL28483533 | 0.74 | EGFR (0.31) | KCNH2 | |
| Ammonia Solution, Strong SCHEMBL7822449 | 0.72 | F2 (0.35) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492376-B | Bicyclic heterocycle compounds and their uses in therapy | ASTEX THERAPEUTICS LTD | 2015-07-22 | — | — | CN | disclosed |
| CN-103492376-A | Bicyclic heterocycle compounds and their uses in therapy | ASTEX THERAPEUTICS LTD | 2014-01-01 | — | — | CN | disclosed |
| CN-102791131-A | Compounds and methods | GLAXOSMITHKLINE LLC | 2012-11-21 | — | — | CN | disclosed |
| CN-100422214-C | Emitter-binding peptides that produce a change in the spectral emission properties of the emitter | MORPHOSYS AG (DE) | 2008-10-01 | — | — | CN | disclosed |
| CN-1820027-A | Emitter-binding peptides that produce a change in the spectral emission properties of the emitter | MORPHOSYS AG (DE) | 2006-08-16 | — | — | CN | disclosed |
| CN-1541098-A | Combination therapy for treatment of cancer | �ո��� | 2004-10-27 | — | — | CN | disclosed |
| EP-1255752-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060814-A2 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2001-08-23 | — | — | WO | disclosed |