Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | F12 | P00748 | 3/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29557640 | 1.00 | HPGD (0.33) | HPGDCCKBRMTNR1AMTNR1BPAX8 | |
| SCHEMBL7673571 | 0.81 | KCNH2 (0.33) | HPGDCCKBRMTNR1AMTNR1BPAX8 | |
| SCHEMBL3139041 | 0.81 | CA1 (0.33) | CCKBRCHRNB4CHRNA3KMT2AALDH1A1 | |
| Methylamine SCHEMBL28799881 | 0.81 | MTNR1A (0.33) | HPGDCCKBRMTNR1AMTNR1BPAX8 | |
| Hydrochloric Acid SCHEMBL27712072 | 0.80 | KCNH2 (0.33) | HPGDCCKBRMTNR1AMTNR1BPAX8 | |
| Hydrochloric Acid SCHEMBL27907053 | 0.80 | CA1 (0.33) | CCKBRCHRNB4CHRNA3KMT2AALDH1A1 | |
| SCHEMBL27582656 | 0.74 | CHRNB4 (0.37) | CCKBRMTNR1AMTNR1BPAX8CHRNB4 | |
| SCHEMBL22864428 | 0.70 | CCKBR (0.32) | CCKBRMTNR1AMTNR1BPAX8CHRNB4 | |
| SCHEMBL3696128 | 0.70 | CCKBR (0.38) | CCKBRPAX8 | |
| SCHEMBL21192935 | 0.70 | CCKBR (0.38) | CCKBRMTNR1AMTNR1BKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315796-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-114315796-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021000935-A1 | HPK1 INHIBITORS AND USES THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2021-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | HIPK1, SIK1, PGK1 | HPGD 541/4885CCKBR 4089/4885MTNR1A 4501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.