Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666959 | 0.90 | OPRD1 (0.59) | OPRD1OPRK1OPRM1PKMSLC6A7 | |
| SCHEMBL7668213 | 0.89 | OPRD1 (0.53) | OPRD1OPRK1OPRM1HPGDKDM4E | |
| SCHEMBL7673036 | 0.85 | OPRD1 (0.51) | OPRD1OPRK1OPRM1HPGDALDH1A1 | |
| SCHEMBL7667107 | 0.81 | OPRD1 (0.51) | OPRD1OPRK1OPRM1HPGDSMN1; SMN2 | |
| SCHEMBL7668023 | 0.81 | OPRD1 (0.51) | OPRD1OPRK1OPRM1ALDH1A1TSHR | |
| SCHEMBL6171193 | 0.78 | OPRD1 (0.52) | OPRD1OPRK1OPRM1HPGDKDM4E | |
| SCHEMBL7665821 | 0.77 | OPRD1 (0.68) | OPRD1OPRK1OPRM1KDM4E | |
| SCHEMBL7665165 | 0.77 | OPRD1 (0.56) | OPRD1OPRK1OPRM1ALDH1A1TSHR | |
| SCHEMBL7665822 | 0.77 | OPRD1 (0.51) | OPRD1OPRK1OPRM1HPGDHDAC6 | |
| SCHEMBL4878168 | 0.74 | CA12 (0.45) | OPRD1HPGDKDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444679-B1 | NEUROLOGICAL AND GASTROINTESTINAL DISORDERS; DELTA OPIOID LIGANDS OR OPIOID RECEPTORS | PFIZER INC | 2002-09-03 | — | — | US | disclosed |