Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668213 | 0.92 | OPRD1 (0.53) | OPRD1OPRK1OPRM1HPGDALDH1A1 | |
| SCHEMBL7672992 | 0.89 | OPRD1 (0.65) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7674063 | 0.85 | OPRD1 (0.47) | OPRD1OPRK1OPRM1HPGDALDH1A1 | |
| SCHEMBL7667107 | 0.84 | OPRD1 (0.51) | OPRD1OPRK1OPRM1HPGDALDH1A1 | |
| SCHEMBL7668023 | 0.84 | OPRD1 (0.51) | OPRD1OPRK1OPRM1ALDH1A1LMNA | |
| SCHEMBL6597970 | 0.82 | OPRD1 (0.52) | OPRD1OPRK1OPRM1 | |
| SCHEMBL7665165 | 0.82 | OPRD1 (0.56) | OPRD1OPRK1OPRM1ALDH1A1LMNA | |
| SCHEMBL7665822 | 0.82 | OPRD1 (0.51) | OPRD1OPRK1OPRM1HPGDHDAC3 | |
| SCHEMBL6171193 | 0.81 | OPRD1 (0.52) | OPRD1OPRK1OPRM1HPGDALDH1A1 | |
| SCHEMBL7665821 | 0.80 | OPRD1 (0.68) | OPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444679-B1 | NEUROLOGICAL AND GASTROINTESTINAL DISORDERS; DELTA OPIOID LIGANDS OR OPIOID RECEPTORS | PFIZER INC | 2002-09-03 | — | — | US | disclosed |
| EP-1038872-A1 | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands | Pfizer Products Inc. (US) | 2000-09-27 | — | — | EP | disclosed |