Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 9/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665850 | 0.89 | ALDH1A1 (0.53) | OPRD1OPRK1OPRM1L3MBTL1ALDH1A1 | |
| SCHEMBL7665600 | 0.88 | OPRD1 (0.71) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6173909 | 0.87 | OPRD1 (0.64) | OPRD1OPRK1OPRM1L3MBTL1 | |
| SCHEMBL7671714 | 0.87 | LMNA (0.55) | OPRD1OPRK1OPRM1L3MBTL1ALDH1A1 | |
| SCHEMBL7668213 | 0.84 | OPRD1 (0.53) | OPRD1OPRK1OPRM1ALDH1A1CYP2D6 | |
| SCHEMBL7667107 | 0.83 | OPRD1 (0.51) | OPRD1OPRK1OPRM1L3MBTL1ALDH1A1 | |
| SCHEMBL6600233 | 0.83 | OPRD1 (0.49) | OPRD1OPRK1OPRM1ALDH1A1CYP2D6 | |
| SCHEMBL7665822 | 0.82 | OPRD1 (0.51) | OPRD1OPRK1OPRM1CYP2D6TSHR | |
| SCHEMBL7673036 | 0.82 | OPRD1 (0.51) | OPRD1OPRK1OPRM1ALDH1A1TSHR | |
| SCHEMBL7672418 | 0.81 | OPRD1 (0.69) | OPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444679-B1 | NEUROLOGICAL AND GASTROINTESTINAL DISORDERS; DELTA OPIOID LIGANDS OR OPIOID RECEPTORS | PFIZER INC | 2002-09-03 | — | — | US | disclosed |
| EP-1038872-A1 | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands | Pfizer Products Inc. (US) | 2000-09-27 | — | — | EP | disclosed |
| JP-2000247969-A | 4-PHENYL-4-HETEROARYLPIPERIDINE DERIVATIVE | PFIZER PROD INC | 2000-09-12 | — | — | JP | disclosed |