Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332693 | 0.89 | ALDH1A1 (0.61) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL7364681 | 0.87 | RAB9A (0.72) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL29209327 | 0.84 | TDP1 (0.51) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL30749506 | 0.84 | TDP1 (0.51) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL2924686 | 0.84 | RAB9A (0.76) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL1086604 | 0.83 | ALDH1A1 (0.70) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL27565178 | 0.83 | RAB9A (0.55) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL3454297 | 0.82 | CYP1A2 (0.62) | ALDH1A1POLBGAARAB9ATDP1 | |
| SCHEMBL8177633 | 0.81 | KDM4E (0.62) | P2RY1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL11247603 | 0.81 | NPC1 (0.63) | ALDH1A1POLBGAARAB9AP2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| CN-1254335-A | Nicotinamide derivatives | PFIZER PROD INC (US) | 2000-05-24 | — | — | CN | disclosed |
| US-4327218-A | HERBICIDES | STAUFFER CHEMICAL COMPANY (US) | 1982-04-27 | — | — | US | disclosed |
| US-4270946-A | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof | STAUFFER CHEMICAL COMPANY (US) | 1981-06-02 | — | — | US | disclosed |
| US-4251263-A | N-substituted, 2-phenoxynicotinamide compounds and the herbicidal use thereof | STAUFFER CHEMICAL COMPANY (US) | 1981-02-17 | — | — | US | disclosed |