Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.57 |
| ▸ | MMP2 | P08253 | 5/20 | 0.57 |
| ▸ | MMP14 | P50281 | 4/20 | 0.57 |
| ▸ | MMP9 | P14780 | 4/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.57 |
| ▸ | MMP13 | P45452 | 3/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673929 | 0.85 | MMP2 (0.50) | MMP1MMP2MMP14MMP9ADAM17 | |
| SCHEMBL7673657 | 0.80 | HSD17B10 (0.52) | MMP1MMP2MMP14MMP9ADAM17 | |
| SCHEMBL7669154 | 0.80 | KMT2A (0.49) | MMP1MMP2MMP14MMP9ADAM17 | |
| SCHEMBL7669158 | 0.80 | KMT2A (0.49) | MMP1MMP2MMP14MMP9ADAM17 | |
| SCHEMBL4832606 | 0.80 | CYP2D6 (0.62) | MMP1MMP2MMP14MMP9ADAM17 | |
| SCHEMBL7674174 | 0.79 | MMP1 (0.61) | MMP1MMP2MMP14MMP9ADAM17 | |
| SCHEMBL697595 | 0.77 | KMT2A (0.60) | KMT2A | |
| SCHEMBL7471734 | 0.76 | PKM (0.72) | MMP1MMP2MMP14MMP9ADAM17 | |
| SCHEMBL26381709 | 0.76 | PKM (0.53) | MMP1MMP2MMP14MMP9MMP13 | |
| SCHEMBL7667468 | 0.76 | MMP1 (0.61) | MMP1MMP2MMP14MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |