Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | FAAH | O00519 | 2/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 3/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 3/20 | 0.36 |
| ▸ | ADH1A | P07327 | 3/20 | 0.36 |
| ▸ | ADH1B | P00325 | 2/20 | 0.36 |
| ▸ | ADH7 | P40394 | 2/20 | 0.36 |
| ▸ | ADH4 | P08319 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30481037 | 0.93 | TSHR (0.73) | TSHRFAAHTRPV1ALDH1A1HIF1A | |
| SCHEMBL7677802 | 0.93 | TSHR (0.62) | TSHRFAAHTRPV1ALDH1A1HIF1A | |
| SCHEMBL25710164 | 0.91 | TSHR (0.70) | TSHRFAAHTRPV1ALDH1A1HIF1A | |
| SCHEMBL9431925 | 0.91 | TSHR (0.61) | TSHRFAAHTRPV1ALDH1A1HIF1A | |
| SCHEMBL1638660 | 0.91 | TSHR (0.54) | TSHRFAAHTRPV1ALDH1A1HIF1A | |
| SCHEMBL7628246 | 0.88 | TSHR (0.55) | TSHRFAAHTRPV1ALDH1A1HIF1A | |
| Butanal SCHEMBL28067135 | 0.88 | ALDH1A1 (0.60) | TSHRFAAHTRPV1ALDH1A1HIF1A | |
| SCHEMBL25058741 | 0.84 | TSHR (0.59) | TSHRFAAHTRPV1ALDH1A1KDM5A | |
| SCHEMBL22642669 | 0.84 | TSHR (0.59) | TSHRFAAHTRPV1ALDH1A1KDM5A | |
| SCHEMBL22920282 | 0.84 | TSHR (0.59) | TSHRFAAHTRPV1ALDH1A1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380197-B1 | FOR TREATING AND PREVENTING A PLETHORA OF DISEASES INCLUDING DIABETES | AVENTIS PHARMA S. A. (FR) | 2002-04-30 | — | — | US | claimed |
| EP-1001943-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999003843-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | claimed |
| US-6380197-B1 | FOR TREATING AND PREVENTING A PLETHORA OF DISEASES INCLUDING DIABETES | AVENTIS PHARMA S. A. (FR) | 2002-04-30 | — | — | US | disclosed |
| EP-1001943-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999003843-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | disclosed |