Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.62 |
| ▸ | DRD3 | P35462 | 5/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 7/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Mercaptopyridine SCHEMBL8140323 | 0.91 | DRD2 (0.64) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL13875122 | 0.90 | SIGMAR1 (0.71) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL13875120 | 0.86 | SIGMAR1 (0.69) | DRD2DRD3SIGMAR1HTR7ALDH1A1 | |
| SCHEMBL7677755 | 0.83 | SIGMAR1 (0.55) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL2927397 | 0.81 | ALDH1A1 (0.77) | DRD2SIGMAR1HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL11465528 | 0.81 | SIGMAR1 (0.76) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL8128060 | 0.80 | SIGMAR1 (0.71) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| Ammonia Solution, Strong SCHEMBL11284383 | 0.80 | ALDH1A1 (0.75) | DRD2SIGMAR1HTR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL8129982 | 0.79 | SIGMAR1 (0.70) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL1253143 | 0.79 | SIGMAR1 (0.69) | DRD2DRD3ADRA1ASIGMAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444674-B1 | HIGH AFFINITY FOR THE DOPAMINE D3 RECEPTOR; SCHIZOPHRENIA, DEPRESSION, NEUROSES AND PSYCHOSES | ABBOTT LABORATORIES | 2002-09-03 | — | — | US | disclosed |
| US-6342604-B1 | TREATING SCHIZOPHRENIA, DEPRESSION, NEUROSES AND PSYCHOSES WHICH RESPOND TO DOPAMINE D3 LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-29 | — | — | US | disclosed |