Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14938652 | 0.75 | CYP2A13 (0.47) | HRH3CXCR4LMNAL3MBTL1 | |
| SCHEMBL3546491 | 0.69 | PIK3CD (0.41) | PIK3CAPIK3CBPIK3CDKDM4ELMNA | |
| SCHEMBL3548595 | 0.69 | SMN1; SMN2 (0.44) | PIK3CAPIK3CBPIK3CDKDM4ENPSR1 | |
| SCHEMBL7678947 | 0.67 | NPSR1 (0.43) | HRH3PIK3CAPIK3CBPIK3CDMC4R | |
| SCHEMBL15100913 | 0.67 | MGLL (0.62) | KDM4ELMNACHKA | |
| SCHEMBL15100829 | 0.67 | MGLL (0.57) | HRH3KDM4ETDP1NPSR1HRH4 | |
| SCHEMBL7681827 | 0.67 | PIK3CA (0.47) | HRH3PIK3CAATRATRIPMC4R | |
| SCHEMBL17493416 | 0.66 | PDE10A (0.40) | PIK3CAPIK3CBPIK3CDATRATRIP | |
| SCHEMBL3763677 | 0.65 | PDE4A (0.46) | KDM4ELMNANPSR1 | |
| SCHEMBL14355869 | 0.65 | CYP2A13 (0.58) | HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |