Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681981 | 0.88 | HRH4 (0.39) | HRH4SLC2A1MC4RHTR3EHTR3B | |
| SCHEMBL7676496 | 0.71 | MC4R (0.48) | HRH4SLC2A1MC4RHTR3A | |
| SCHEMBL5897129 | 0.70 | HRH4 (0.55) | NPSR1HRH4KMT2AHRH3PIK3CB | |
| SCHEMBL7679970 | 0.68 | MC4R (0.42) | HRH4KMT2AHRH3CYP1A2CYP2D6 | |
| SCHEMBL7674618 | 0.67 | HRH3 (0.37) | NPSR1HRH4PIK3CAHRH3PIK3CB | |
| SCHEMBL5897044 | 0.66 | HRH4 (0.50) | NPSR1HRH4KMT2APIK3CBCRHBP | |
| SCHEMBL7681827 | 0.65 | PIK3CA (0.47) | NPSR1HRH4KMT2APIK3CAHRH3 | |
| SCHEMBL190232 | 0.64 | PIK3CA (0.63) | PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL12727282 | 0.64 | PIK3CA (0.46) | HRH4KMT2APIK3CAPIK3CBPIK3CD | |
| SCHEMBL5896965 | 0.64 | HRH3 (0.43) | NPSR1HRH4KMT2APIK3CAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1146542-C | Benzamide derivatives and their use as cytokine inhibitors | — | 2004-04-21 | — | — | CN | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| CN-1319092-A | Benzamide derivatives and their use as cytokine inhibitors | ASTRAZENECA AB (SE) | 2001-10-24 | — | — | CN | disclosed |