SCHEMBL7675588

SCHEMBL7675588

NC(=O)/C=C\C(=O)NC(N)=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.52
CACNA1B Q00975 1/20 0.52
APBA1 Q02410 1/20 0.52
RAB9A P51151 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
ALDH1A1 P00352 5/20 0.41
HTT P42858 5/20 0.41
DDAH1 O94760 1/20 0.41
CRBN Q96SW2 1/20 0.39
LMNA P02545 5/20 0.36
MCL1 Q07820 1/20 0.36
GAA P10253 1/20 0.35
PKM P14618 2/20 0.34
NLRP1 Q9C000 1/20 0.34
TSHR P16473 3/20 0.33
NFKB1 P19838 2/20 0.33
CYP1A2 P05177 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
THPO P40225 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9728289 1.00 MAPT (0.52) MAPTCACNA1BAPBA1RAB9ANPSR1
SCHEMBL9728297 1.00 MAPT (0.52) MAPTCACNA1BAPBA1RAB9ANPSR1
SCHEMBL989812 0.81 MAPT (0.50) MAPTCACNA1BAPBA1RAB9ANPSR1
SCHEMBL989815 0.81 MAPT (0.50) MAPTCACNA1BAPBA1RAB9ANPSR1
SCHEMBL989814 0.81 MAPT (0.50) MAPTCACNA1BAPBA1RAB9ANPSR1
SCHEMBL27995703 0.79 CRBN (0.48) MAPTCACNA1BAPBA1RAB9ANPSR1
SCHEMBL9227811 0.77 MAPT (0.37) MAPTCACNA1BAPBA1RAB9ANPSR1
SCHEMBL203011 0.76
SCHEMBL3814286 0.76
SCHEMBL15084289 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11400042-B2 Process for treating keratin fibres, comprising the application of a composition comprising urea or a derivative thereof, a polyol and an amino silicone L'OREAL (FR) 2022-08-02 US claimed
US-11298305-B2 Compositions and methods for improving the appearance of the hair L'OREAL (FR) 2022-04-12 US claimed
EP-2988830-B1 COMPOSITION FOR STRAIGHTENING KERATIN FIBRES, COMPRISING A UREA AND/OR A UREA DERIVATIVE AND A NONIONIC, CATIONIC, AMPHOTERIC OR ANIONIC ASSOCIATIVE POLYMERIC THICKENER, PROCESS AND USE THEREOF OREAL (FR) 2021-03-17 EP claimed
EP-2916808-B1 COMPOSITION COMPRISING A DICARBONYL DERIVATIVE AND METHOD FOR STRAIGHTENING THE HAIR USING THIS COMPOSITION OREAL (FR) 2019-06-26 EP claimed
US-20190167552-A1 COMPOSITIONS AND METHODS FOR IMPROVING THE APPEARANCE OF THE HAIR L'OREAL (FR) 2019-06-06 US claimed
US-20190117551-A1 PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A COMPOSITION COMPRISING A UREA AND/OR A UREA DERIVATIVE AND A POLYMERIC THICKENER L'OREAL (FR) 2019-04-25 US claimed
US-20190021983-A1 PROCESS FOR TREATING KERATIN FIBRES, COMPRISING THE APPLICATION OF A COMPOSITION COMPRISING UREA OR A DERIVATIVE THEREOF, A POLYOL AND AN AMINO SILICONE L'OREAL (FR) 2019-01-24 US claimed
EP-3393435-A1 PROCESS FOR TREATING KERATIN FIBRES, COMPRISING THE APPLICATION OF A COMPOSITION COMPRISING UREA OR A DERIVATIVE THEREOF, A POLYOL AND AN AMINO SILICONE L'Oréal (FR) 2018-10-31 EP claimed
WO-2018000059-A1 COMPOSITIONS AND METHODS FOR IMPROVING THE APPEARANCE OF THE HAIR L'OREAL (FR) 2018-01-04 WO claimed
WO-2017109067-A1 PROCESS FOR TREATING KERATIN FIBRES, COMPRISING THE APPLICATION OF A COMPOSITION COMPRISING UREA OR A DERIVATIVE THEREOF, A POLYOL AND AN AMINO SILICONE L'OREAL (FR) 2017-06-29 WO claimed
US-20160199276-A1 COMPOSITION FOR STRAIGHTENING KERATIN FIBRES, COMPRISING A UREA AND/OR A UREA DERIVATIVE AND A NONIONIC, CATIONIC, AMPHOTERIC OR ANIONIC ASSOCIATIVE POLYMERIC THICKENER, PROCESS AND USE THEREOF L'OREAL (FR) 2016-07-14 US claimed
EP-2988830-A2 COMPOSITION FOR STRAIGHTENING KERATIN FIBRES, COMPRISING A UREA AND/OR A UREA DERIVATIVE AND A NONIONIC, CATIONIC, AMPHOTERIC OR ANIONIC ASSOCIATIVE POLYMERIC THICKENER, PROCESS AND USE THEREOF L'Oréal (FR) 2016-03-02 EP claimed
US-20150305999-A1 COMPOSITION COMPRISING A DICARBONYL DERIVATIVE AND METHOD FOR STRAIGHTENING THE HAIR USING THIS COMPOSITION L'OREAL (FR) 2015-10-29 US claimed
WO-2014174075-A2 COMPOSITION FOR STRAIGHTENING KERATIN FIBRES, COMPRISING A UREA AND/OR A UREA DERIVATIVE AND A NONIONIC, CATIONIC, AMPHOTERIC OR ANIONIC ASSOCIATIVE POLYMERIC THICKENER, PROCESS AND USE THEREOF L'OREAL (FR) 2014-10-30 WO claimed
WO-2025018432-A1 PROCESS FOR TREATING KERATIN FIBERS L'OREAL (FR) 2025-01-23 WO disclosed
CN-108430442-B Method for treating keratin fibres comprising the application of a composition comprising urea or a derivative thereof, a polyol and an aminosilicone 欧莱雅 2022-08-09 CN disclosed
US-11400042-B2 Process for treating keratin fibres, comprising the application of a composition comprising urea or a derivative thereof, a polyol and an amino silicone L'OREAL (FR) 2022-08-02 US disclosed
US-4943612-A ANIONIC, CATIONIC, AND NONIONIC EMULSIFIERS LION CORPORATION (JP) 1990-07-24 US disclosed
EP-0273605-A2 Ultra-fine particulated polymer latex and composition containing the same LION CORPORATION (JP) 1988-07-06 EP disclosed
EP-0228879-A2 Process for production of ultrafine polymer latex LION CORPORATION (JP) 1987-07-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190021983-A1 PROCESS FOR TREATING KERATIN FIBRES, COMPRISING THE APPLICATION OF A COMPOSITION COMPRISING UREA OR A DERIVATIVE THEREOF, A POLYOL AND AN AMINO SILICONE KRT18, CUTA, PUF60 MAPT 112/4885CACNA1B 4718/4885APBA1 2744/4885
US-20190167552-A1 COMPOSITIONS AND METHODS FOR IMPROVING THE APPEARANCE OF THE HAIR KRT18, OAT, CKMT1A; CKMT1B MAPT 123/4885CACNA1B 3782/4885APBA1 3769/4885
US-11298305-B2 Compositions and methods for improving the appearance of the hair KRT18, OAT, CKMT1A; CKMT1B MAPT 123/4885CACNA1B 3782/4885APBA1 3769/4885
US-20190117551-A1 PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A COMPOSITION COMPRISING A UREA AND/OR A UREA DERIVATIVE AND A POLYMERIC THICKENER KRT18, CUTA, MARK1 MAPT 44/4885CACNA1B 4857/4885APBA1 1627/4885
US-20150305999-A1 COMPOSITION COMPRISING A DICARBONYL DERIVATIVE AND METHOD FOR STRAIGHTENING THE HAIR USING THIS COMPOSITION KRT18, MAPT, CUTA MAPT 2/4885CACNA1B 3511/4885APBA1 1150/4885
US-20160199276-A1 COMPOSITION FOR STRAIGHTENING KERATIN FIBRES, COMPRISING A UREA AND/OR A UREA DERIVATIVE AND A NONIONIC, CATIONIC, AMPHOTERIC OR ANIONIC ASSOCIATIVE POLYMERIC THICKENER, PROCESS AND USE THEREOF KRT18, CUTA, MARK1 MAPT 41/4885CACNA1B 4736/4885APBA1 1367/4885
US-11400042-B2 Process for treating keratin fibres, comprising the application of a composition comprising urea or a derivative thereof, a polyol and an amino silicone KRT18, CUTA, PUF60 MAPT 112/4885CACNA1B 4718/4885APBA1 2744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.