Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352791 | 0.81 | KMT2A (0.51) | MAPTCYP1A2CYP2D6KMT2AMEN1 | |
| SCHEMBL27892245 | 0.79 | KMT2A (0.46) | MAPTCYP1A2CYP2D6KMT2AMEN1 | |
| SCHEMBL856718 | 0.76 | MAPT (0.61) | MAPTCYP1A2CYP2D6KMT2AMEN1 | |
| SCHEMBL27787101 | 0.74 | ATR (0.44) | — | |
| SCHEMBL7676555 | 0.74 | CYP1A2 (0.50) | MAPTCYP1A2CYP2D6KMT2AMEN1 | |
| SCHEMBL21143680 | 0.73 | CRHBP (0.40) | MAPTCYP1A2CYP2D6KMT2AMEN1 | |
| SCHEMBL29762330 | 0.71 | MAPT (0.70) | MAPTCYP1A2CYP2D6KMT2AMEN1 | |
| SCHEMBL856815 | 0.71 | MAPT (0.70) | MAPTCYP1A2CYP2D6KMT2AMEN1 | |
| SCHEMBL27794167 | 0.71 | AURKA (0.40) | — | |
| SCHEMBL1110658 | 0.70 | PIK3CA (0.50) | MAPTCYP1A2CYP2D6KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |