Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960029 | 0.81 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL2052164 | 0.73 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| SCHEMBL6760292 | 0.69 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL5533925 | 0.67 | MAPT (0.46) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL5636904 | 0.67 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| Awd-12-281 SCHEMBL155120 | 0.63 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| SCHEMBL2052162 | 0.63 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| Awd-12-281 SCHEMBL29413256 | 0.63 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| Awd-12-281 SCHEMBL5638136 | 0.62 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4D | |
| Awd-12-281 SCHEMBL5638122 | 0.62 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020119971-A1 | Antiinflammatory agents; skin disorders; central nervous system disorders | ELBION AG (DE) | 2002-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020119971-A1 | Antiinflammatory agents; skin disorders; central nervous system disorders | PDE4A, TPH1, PDE12 | PDE4A 1/4885PDE4B 4/4885PDE4C 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.