Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | APOL1 | O14791 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960029 | 0.86 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL5888118 | 0.84 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL5893957 | 0.76 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5636904 | 0.75 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL8637415 | 0.74 | KDM4E (0.55) | CTSVCTSLMAOAMAOBGABRA1 | |
| SCHEMBL5532547 | 0.73 | MAPT (0.45) | ACHE | |
| SCHEMBL5533925 | 0.72 | MAPT (0.46) | PDE4APDE4BPDE4CPDE4DALOX5 | |
| SCHEMBL5531131 | 0.69 | RAB9A (0.47) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL8136752 | 0.69 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7675615 | 0.69 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040266760-A1 | 5-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | ELBION AG (DE) | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266760-A1 | 5-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | HTR5A, HTR4, HNMT | PDE4A 6/4885PDE4B 4/4885PDE4C 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.