Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 0.55 |
| ▸ | PDE4A | P27815 | 19/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.55 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344275 | 0.82 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL6958267 | 0.79 | ALDH1A1 (0.37) | PDE4B | |
| SCHEMBL6950190 | 0.79 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL3471216 | 0.79 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL6953997 | 0.74 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL8311511 | 0.72 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL6833145 | 0.72 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL6963861 | 0.72 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL8269400 | 0.71 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL4700850 | 0.71 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6353010-B1 | ENZYME INHIBITORS TUMOR NECROSIS FACTOR AND PHOSPHODIESTERASE FOR ANTIINFLAMMATORY AGENTS | DARWIN DISCOVERY, LTD. (GB) | 2002-03-05 | — | — | US | claimed |