Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.53 |
| ▸ | CTSS | P25774 | 4/20 | 0.53 |
| ▸ | CTSB | P07858 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797250 | 1.00 | CTSL (0.53) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL3726928 | 0.91 | CTSL (0.47) | CTSLCTSSCTSBMEN1KMT2A | |
| SCHEMBL8148353 | 0.90 | CYP3A4 (0.45) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL7787420 | 0.81 | CYP3A4 (0.38) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL5689754 | 0.79 | CTSL (0.57) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL5689757 | 0.79 | CTSL (0.57) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL3741299 | 0.79 | CTSL (0.57) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL8662503 | 0.77 | CTSB (0.70) | CTSLCTSSCTSBCYP3A4CYP2D6 | |
| SCHEMBL3728996 | 0.76 | ATM (0.48) | CTSLCTSSCTSBCTSKCASP3 | |
| SCHEMBL3737297 | 0.76 | MEN1 (0.55) | CTSLCTSSCTSBCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458772-B1 | Prodrugs | MEDIVIR AB (SE) | 2002-10-01 | — | — | US | disclosed |