Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.33 |
| ▸ | DRD1 | P21728 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32668926 | 0.81 | MAPK1 (0.53) | MAPK1SMN1; SMN2HRH1SLC6A15FNTA | |
| SCHEMBL4457894 | 0.81 | MAPK1 (0.53) | MAPK1SMN1; SMN2HRH1SLC6A15FNTA | |
| SCHEMBL5475539 | 0.70 | HRH1 (0.54) | MAPK1SMN1; SMN2HRH1SLC6A15FNTA | |
| SCHEMBL9663359 | 0.69 | SMN1; SMN2 (0.36) | MAPK1SMN1; SMN2FNTAFNTBAVPR1A | |
| SCHEMBL8877017 | 0.69 | MAPK1 (0.41) | MAPK1SMN1; SMN2HRH1FNTAFNTB | |
| SCHEMBL9663354 | 0.69 | MAPK1 (0.34) | MAPK1SMN1; SMN2FNTAFNTBTDP1 | |
| SCHEMBL9215850 | 0.69 | DRD2 (0.41) | MAPK1SMN1; SMN2FNTAFNTBTDP1 | |
| SCHEMBL8878095 | 0.69 | DRD4 (0.39) | MAPK1SMN1; SMN2FNTAFNTBDRD2 | |
| SCHEMBL8878464 | 0.69 | FNTA (0.43) | MAPK1SMN1; SMN2HRH1SLC6A15FNTA | |
| SCHEMBL9832235 | 0.68 | MAPK1 (0.53) | MAPK1SMN1; SMN2FNTAFNTBSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492381-B1 | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases | SCHERING CORP. | 2002-12-10 | — | — | US | disclosed |
| EP-0723538-B1 | TRICYCLIC CARBAMATE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES | SCHERING CORP (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6300338-B1 | AS ANTITUMOR AGENT | SCHERING CORPORATION | 2001-10-09 | — | — | US | disclosed |
| US-6075025-A | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases | SCHERING CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| US-5977128-A | ENZYME INHIBITORS | SCHERING CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |