Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | OGA | O60502 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26416118 | 0.80 | HRH3 (0.45) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL10136842 | 0.76 | HRH3 (0.49) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL12988798 | 0.72 | HRH3 (0.52) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL13634230 | 0.72 | HRH3 (0.55) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL3559247 | 0.72 | HRH3 (0.55) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL3511935 | 0.71 | L3MBTL1 (0.54) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL4472290 | 0.71 | L3MBTL1 (0.54) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL458365 | 0.71 | HRH3 (0.48) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL4469579 | 0.70 | SMN1; SMN2 (0.53) | HRH3OGAL3MBTL1DPP4MEN1 | |
| SCHEMBL3555940 | 0.70 | HRH3 (0.44) | HRH3OGAL3MBTL1DPP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498161-B1 | TREATING INFECTION BY HIV; DELAYING OF THE ONSET OF AIDS; ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS OR RHEUMATOID ARTHRITIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |
| WO-2000059498-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |