Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 3/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962684 | 1.00 | LMNA (0.55) | LMNASMN1; SMN2HTTCTSSCTSL | |
| SCHEMBL7676954 | 1.00 | LMNA (0.55) | LMNASMN1; SMN2HTTCTSSCTSL | |
| SCHEMBL17825637 | 0.90 | LMNA (0.49) | LMNASMN1; SMN2HTTCTSSCTSL | |
| SCHEMBL24736141 | 0.88 | LMNA (0.52) | LMNASMN1; SMN2HTTCTSSCTSL | |
| SCHEMBL17825663 | 0.87 | CNR2 (0.47) | LMNASMN1; SMN2HTTCTSSCTSL | |
| SCHEMBL7310621 | 0.86 | HSD17B10 (0.59) | LMNASMN1; SMN2HTTCTSSCTSL | |
| SCHEMBL28088132 | 0.85 | SLC1A3 (0.61) | LMNASMN1; SMN2HTTCTSSCTSL | |
| SCHEMBL7448245 | 0.85 | CTSS (0.47) | LMNASMN1; SMN2HTTCTSSCTSL | |
| SCHEMBL28491869 | 0.83 | SMN1; SMN2 (0.51) | LMNASMN1; SMN2HTTHSD17B10ATM | |
| SCHEMBL13569333 | 0.83 | SMN1; SMN2 (0.62) | LMNASMN1; SMN2HTTCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417203-B1 | HETEROCYCLIC AMIDES | PFIZER INC. | 2002-07-09 | — | — | US | disclosed |