Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184244 | 0.85 | CTSS (0.62) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7676950 | 0.85 | LMNA (0.55) | CTSSCTSLCTSBLMNASMN1; SMN2 | |
| SCHEMBL6962684 | 0.85 | LMNA (0.55) | CTSSCTSLCTSBLMNASMN1; SMN2 | |
| SCHEMBL7676954 | 0.85 | LMNA (0.55) | CTSSCTSLCTSBLMNASMN1; SMN2 | |
| SCHEMBL17825637 | 0.82 | LMNA (0.49) | CTSSCTSLCTSBLMNASMN1; SMN2 | |
| SCHEMBL17825663 | 0.81 | CNR2 (0.47) | CTSSCTSLLMNASMN1; SMN2HTT | |
| SCHEMBL28395771 | 0.80 | CTSB (0.47) | CTSSCTSBCYP3A4CYP2D6TSHR | |
| SCHEMBL4367316 | 0.80 | CTSB (0.47) | CTSSCTSBCYP3A4CYP2D6TSHR | |
| SCHEMBL7138629 | 0.78 | CTSL (0.41) | CTSSCTSLCTSBCASP1ATM | |
| SCHEMBL8659974 | 0.75 | LMNA (0.50) | CTSSCTSLCTSBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001027096-A9 | AMINOMETHYL-(HETERO)ARYL DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | PROTHERICS MOLECULAR DESIGN LT (GB) | 2001-07-12 | — | — | WO | disclosed |