Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.45 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 5/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673292 | 0.85 | KMO (0.50) | HTR2CHTR2APRMT5HTR7 | |
| SCHEMBL8959694 | 0.78 | HTR2C (0.58) | HTR2CHTR2APRMT5HDAC3HDAC1 | |
| SCHEMBL8959486 | 0.78 | HTR2C (0.58) | HTR2CHTR2APRMT5HDAC3HDAC1 | |
| SCHEMBL8959627 | 0.77 | HTR2C (0.60) | HTR2CHTR2AHDAC1HDAC8HDAC6 | |
| SCHEMBL7677257 | 0.73 | HTR2C (0.43) | HTR2CHTR2APRMT5PRMT1HTR7 | |
| SCHEMBL23927929 | 0.72 | HTR2C (0.51) | HTR2CHTR2APRMT5HTR7HDAC3 | |
| SCHEMBL7258385 | 0.72 | HTR2C (0.50) | HTR2CHTR2APRMT5PRMT1HTR7 | |
| SCHEMBL7253587 | 0.71 | HTR2C (0.55) | HTR2CHTR2APRMT5PRMT1HTR7 | |
| SCHEMBL7253589 | 0.71 | HTR2C (0.55) | HTR2CHTR2APRMT5PRMT1HTR7 | |
| SCHEMBL7253595 | 0.71 | HTR2C (0.55) | HTR2CHTR2APRMT5PRMT1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380238-B1 | FOR THERAPY OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS, AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-30 | — | — | US | disclosed |