Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | GLA | P06280 | 5/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.63 |
| ▸ | GAA | P10253 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.63 |
| ▸ | DRD1 | P21728 | 2/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7253023 | 0.98 | KDM4E (0.67) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL6886512 | 0.84 | CFD (0.47) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL6771631 | 0.84 | KMT2A (0.72) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL6762612 | 0.83 | CFD (0.49) | ADRA1AADRA1BCFD | |
| SCHEMBL6765436 | 0.82 | ADRA1A (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6807917 | 0.82 | KDM4E (0.79) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL6762675 | 0.81 | CFD (0.44) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL6762678 | 0.81 | CFD (0.44) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL11630579 | 0.81 | KDM4E (0.94) | KDM4EALDH1A1HPGDGLAHSD17B10 | |
| Hydrochloric Acid SCHEMBL11631623 | 0.80 | KDM4E (0.94) | KDM4EALDH1A1HPGDGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020049322-A1 | Quinoline and quinazoline compounds useful in therapy | COLLIS ALAN JOHN (GB) | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049322-A1 | Quinoline and quinazoline compounds useful in therapy | NQO2, RFT1, IDH3B | KDM4E 2989/4885ALDH1A1 514/4885HPGD 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.