Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677866 | 0.87 | NPC1 (0.54) | ADORA2ANPC1RAB9AKDM4EALOX15 | |
| SCHEMBL7316592 | 0.86 | PKM (0.42) | ADORA2AALOX15 | |
| Hydrochloric Acid SCHEMBL7317675 | 0.85 | PKM (0.44) | ADORA2AALOX15 | |
| SCHEMBL7680781 | 0.85 | HRH3 (0.39) | ADORA2ATP53SMN1; SMN2ALOX15 | |
| SCHEMBL7680441 | 0.85 | ADORA2A (0.50) | ADORA2AALOX15 | |
| SCHEMBL7680843 | 0.85 | HRH3 (0.36) | ADORA2ANPC1RAB9AALOX15 | |
| SCHEMBL7678308 | 0.82 | ADORA2A (0.56) | ADORA2ANPC1RAB9A | |
| SCHEMBL7678155 | 0.82 | PSEN1 (0.41) | ADORA2A | |
| SCHEMBL7319679 | 0.81 | ALOX15 (0.35) | ADORA2ANPC1RAB9ATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7319888 | 0.80 | ALOX15 (0.35) | ADORA2ANPC1RAB9ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489337-B1 | TREATMENT OF ALZHEIMER'S DISEASE, EPILEPSY, EATING DISORDERS, LEARNING AND MEMORY DISORDERS, MIGRAINE, SLEEP/WAKE DISORDERS, ALLERGIC RHINITIS, SCHIZOPHRENIA, MILD COGNITIVE IMPAIRMENT, AND ASTHMA | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-12-03 | — | — | US | disclosed |
| WO-2001074813-A2 | METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | disclosed |
| US-4871745-A | LOCAL ANESTHETICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |
| US-4791117-A | LOCAL ANTESTHETICS, ANTISECRETORY AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-12-13 | — | — | US | disclosed |
| US-4727145-A | LOCAL ANESTHETICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |