Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 16/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472951 | 0.82 | EPAS1 (0.39) | GLP1RTSHRDCTPP1MEN1KMT2A | |
| SCHEMBL7476184 | 0.82 | GLP1R (0.44) | GLP1RTSHRDCTPP1MEN1KMT2A | |
| SCHEMBL5722832 | 0.80 | GLP1R (0.46) | GLP1RTSHRDCTPP1 | |
| SCHEMBL5722680 | 0.80 | TSHR (0.55) | GLP1RTSHRDCTPP1GRIN2DGRIN3B | |
| SCHEMBL6932438 | 0.77 | ALDH1A1 (0.41) | TSHRMEN1KMT2A | |
| SCHEMBL6934708 | 0.75 | MEN1 (0.59) | MEN1KMT2A | |
| SCHEMBL7473964 | 0.74 | HRH4 (0.39) | DCTPP1MEN1KMT2A | |
| SCHEMBL6680601 | 0.73 | HRH4 (0.38) | GLP1R | |
| SCHEMBL7676206 | 0.73 | HRH4 (0.38) | — | |
| SCHEMBL7465352 | 0.73 | EPAS1 (0.40) | GLP1RTSHRDCTPP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |
| EP-0885212-A1 | QUINOXALINEDIONES | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032873-A1 | QUINOXALINEDIONES | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-09-12 | — | — | WO | disclosed |