Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 3/20 | 0.40 |
| ▸ | VEGFA | P15692 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 5/20 | 0.35 |
| ▸ | GLP1R | P43220 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
| ▸ | ARNT | P27540 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.31 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.31 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472951 | 0.90 | EPAS1 (0.39) | EPAS1VEGFAKIF11GLP1RMAPT | |
| SCHEMBL7471923 | 0.84 | GLP1R (0.41) | EPAS1VEGFAGLP1RMAPTDCTPP1 | |
| SCHEMBL7466999 | 0.81 | AURKA (0.32) | CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL7472189 | 0.79 | EPAS1 (0.40) | EPAS1VEGFAKIF11GLP1RDCTPP1 | |
| SCHEMBL7468210 | 0.75 | CCR4 (0.36) | KIF11GLP1R | |
| SCHEMBL7477664 | 0.74 | KDM4E (0.30) | MAPTKDM4E | |
| SCHEMBL7476184 | 0.73 | GLP1R (0.44) | EPAS1GLP1RMAPTDCTPP1ARNT | |
| SCHEMBL7678635 | 0.73 | GLP1R (0.50) | GLP1RDCTPP1TSHRMEN1KMT2A | |
| SCHEMBL11082077 | 0.68 | KIF11 (0.52) | EPAS1VEGFAKIF11MAPTALDH1A1 | |
| SCHEMBL32668948 | 0.68 | TSHR (0.46) | EPAS1VEGFAKIF11MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |