Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678922 | 0.78 | HRH3 (0.39) | MC4RLMNACHKAKDM4EHRH3 | |
| SCHEMBL7679625 | 0.78 | HRH3 (0.39) | MC4RLMNACHKAKDM4EHRH3 | |
| SCHEMBL7682554 | 0.77 | HRH4 (0.41) | CYP1A2CYP2D6NPC1RAB9AHRH4 | |
| SCHEMBL7680859 | 0.76 | HTR2C (0.38) | — | |
| SCHEMBL27501203 | 0.75 | CHIA (0.35) | LMNAMETAP2KDM4EHRH3CYP2D6 | |
| SCHEMBL7681200 | 0.74 | KDM4E (0.32) | MC4RLMNAKDM4E | |
| SCHEMBL27455478 | 0.74 | KDM4A (0.34) | MC4RLMNAMETAP2KDM4EALDH1A1 | |
| SCHEMBL27471040 | 0.73 | PDE10A (0.39) | HRH3 | |
| SCHEMBL7681799 | 0.71 | JAK3 (0.37) | LMNACHKAKDM4EALDH1A1NPC1 | |
| SCHEMBL19561794 | 0.71 | METAP2 (0.56) | MC4RLMNAMETAP2CHKAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |