Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 9/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.67 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14125467 | 0.76 | POLB (0.66) | POLBTDP1MAPTL3MBTL1RECQL | |
| SCHEMBL1177395 | 0.73 | POLB (1.00) | POLBTDP1MAPTL3MBTL1RECQL | |
| SCHEMBL4421957 | 0.72 | SMN1; SMN2 (0.56) | POLBTDP1MAPTRECQLKMT2A | |
| SCHEMBL1177894 | 0.70 | POLB (0.62) | POLBTDP1MAPTL3MBTL1RECQL | |
| SCHEMBL1782631 | 0.69 | POLB (0.56) | POLBTDP1MAPTL3MBTL1RECQL | |
| SCHEMBL14125492 | 0.68 | POLB (0.59) | POLBTDP1MAPTL3MBTL1RECQL | |
| SCHEMBL7686920 | 0.68 | LDHA (0.44) | POLBRECQLHSD17B10ALDH1A1ALOX12 | |
| SCHEMBL679418 | 0.68 | POLB (0.50) | POLBTDP1MAPTL3MBTL1RECQL | |
| SCHEMBL19296871 | 0.68 | POLB (1.00) | POLBTDP1MAPTL3MBTL1RECQL | |
| SCHEMBL6045417 | 0.67 | ALDH1A1 (1.00) | POLBTDP1MAPTL3MBTL1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |