Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 9/20 | 0.44 |
| ▸ | LDHB | P07195 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685991 | 0.82 | TP53 (0.42) | LDHALDHBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL7568804 | 0.81 | TP53 (0.57) | LDHALDHBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL6804819 | 0.81 | TP53 (0.57) | LDHALDHBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4421957 | 0.73 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2ALDH1A1HTTRECQL | |
| SCHEMBL5309411 | 0.72 | TP53 (0.63) | LDHALDHBPOLBSMN1; SMN2MAP1LC3B | |
| SCHEMBL6074983 | 0.71 | TP53 (0.49) | LDHALDHBPOLBALDH1A1TP53 | |
| SCHEMBL7690082 | 0.70 | POLB (0.36) | POLBSMN1; SMN2ALDH1A1ALOX12HTT | |
| SCHEMBL9925967 | 0.68 | POLB (0.67) | POLBSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL7678960 | 0.68 | POLB (0.67) | POLBALDH1A1ALOX12HTTHSD17B10 | |
| SCHEMBL7685298 | 0.67 | L3MBTL1 (0.45) | POLBSMN1; SMN2ALDH1A1ALOX12HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |