Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | HRH2 | P25021 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507603 | 0.77 | LMNA (0.64) | LMNACYP2D6SLC6A4MAPTSLC6A2 | |
| SCHEMBL8505464 | 0.73 | LMNA (0.44) | LMNACYP2D6SIGMAR1KDM4ESMN1; SMN2 | |
| SCHEMBL11252431 | 0.73 | LMNA (1.00) | LMNACYP2D6SLC6A4MAPTSLC6A2 | |
| SCHEMBL7681700 | 0.73 | LMNA (0.48) | LMNACYP2D6SLC6A4MAPTSLC6A2 | |
| SCHEMBL25066219 | 0.72 | LMNA (0.91) | LMNACYP2D6SLC6A4MAPTSLC6A2 | |
| SCHEMBL7675371 | 0.72 | LMNA (0.54) | LMNACYP2D6SLC6A4MAPTSLC6A2 | |
| SCHEMBL7675246 | 0.72 | LMNA (0.54) | LMNACYP2D6SLC6A4MAPTSLC6A2 | |
| SCHEMBL8504242 | 0.71 | LMNA (0.49) | LMNACYP2D6SLC6A4MAPTSLC6A2 | |
| SCHEMBL4178165 | 0.71 | LMNA (0.52) | LMNACYP2D6SLC6A4MAPTSLC6A2 | |
| SCHEMBL8253828 | 0.71 | LMNA (0.60) | LMNACYP2D6CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387893-B1 | ADRENERGIC BLOCKING AGENT; BENIGN PROSATATIC HYPERPLASIA | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |