Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CHKA | P35790 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136356 | 0.68 | GPR3 (0.36) | — | |
| Hydrochloric Acid SCHEMBL11531395 | 0.66 | MC4R (0.46) | MC4RHTR6CHKAPOLBKDM4E | |
| SCHEMBL221139 | 0.65 | MC4R (1.00) | MC4RLMNACHKAPOLBHRH4 | |
| SCHEMBL2316820 | 0.65 | MC4R (1.00) | MC4RLMNACHKAPOLBHRH4 | |
| SCHEMBL1044943 | 0.65 | MC4R (1.00) | MC4RLMNACHKAPOLBHRH4 | |
| SCHEMBL7654044 | 0.65 | HTT (0.68) | MC4RPOLBKDM4ETDP1 | |
| SCHEMBL7672750 | 0.65 | MC4R (0.48) | MC4RLMNACHKAKDM4ETDP1 | |
| SCHEMBL2511838 | 0.65 | ERN1 (0.64) | MC4RHTR6CHKAPOLBKDM4E | |
| SCHEMBL12123080 | 0.65 | ACHE (0.67) | MC4RHTR6KDM4ETDP1 | |
| SCHEMBL13499604 | 0.65 | FAAH (0.57) | MC4RCHKAKDM4ETDP1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |