Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 8/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | PPARD | Q03181 | 3/20 | 0.54 |
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.52 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3203412 | 0.96 | SERPINE1 (0.64) | SERPINE1PLA2G2APPARGPPARDPPARA | |
| SCHEMBL3386836 | 0.86 | LTB4R (0.66) | SERPINE1PLA2G2APPARGPPARDPPARA | |
| SCHEMBL5894096 | 0.84 | PLA2G2A (0.56) | SERPINE1PLA2G2APPARGPPARDPPARA | |
| SCHEMBL7679894 | 0.82 | LTB4R (0.51) | PLA2G2APPARGPPARDPPARALMNA | |
| SCHEMBL7680496 | 0.80 | SERPINE1 (0.54) | SERPINE1PLA2G2APPARGPPARDPPARA | |
| SCHEMBL3206115 | 0.78 | PLA2G2A (0.57) | SERPINE1PLA2G2APPARDTHRB | |
| SCHEMBL6353598 | 0.78 | PPARD (0.54) | PLA2G2APPARGPPARDPPARALMNA | |
| SCHEMBL27751714 | 0.78 | PPARD (0.54) | PLA2G2APPARGPPARDPPARALMNA | |
| SCHEMBL9023153 | 0.77 | LTB4R (0.63) | PPARGPPARDPPARALMNAALDH1A1 | |
| SCHEMBL4942305 | 0.77 | SERPINE1 (0.81) | SERPINE1PLA2G2ALMNAADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1310706-A | Phospholipase inhibitors | GENETICS INST (US) | 2001-08-29 | — | — | CN | claimed |
| EP-1062205-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | claimed |
| WO-1999043654-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | claimed |
| US-6500853-B1 | ENZYME INHIBITORS SUCH AS 4-((1-BENZHYDRYL-5-(((BUTYLAMINO)-CARBONYL)AMINO)-1H-INDOL-3-YL)METHYL)-3 -METHOXYBENZOIC ACID USED AS ANTIINFLAMMATORY AGENTS FOR PROPHYLAXIS OF ARTHRITIS, INFLAMMATORY BOWEL DISEASE OR ASTHMA | GENETICS INSTITUTE, LLC | 2002-12-31 | — | — | US | disclosed |