Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | PPARD | Q03181 | 2/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28524187 | 0.91 | LTB4R (0.57) | LTB4RPPARGPPARDPPARAALDH1A1 | |
| SCHEMBL28910240 | 0.90 | LTB4R (0.56) | LTB4RKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9732913 | 0.89 | LTB4R (0.59) | LTB4RKMT2AMEN1LTB4R2ALDH1A1 | |
| SCHEMBL21178247 | 0.89 | LTB4R (0.68) | LTB4RKMT2AMEN1NPC1RAB9A | |
| SCHEMBL28530566 | 0.89 | LTB4R (0.52) | LTB4RKMT2AMEN1NPC1RAB9A | |
| SCHEMBL6642863 | 0.88 | LTB4R (0.59) | LTB4RKMT2AMEN1NPC1RAB9A | |
| SCHEMBL27649356 | 0.88 | LTB4R (0.50) | LTB4RKMT2AMEN1NPC1RAB9A | |
| SCHEMBL8685900 | 0.88 | ALDH1A1 (0.64) | LTB4RKMT2AMEN1NPC1RAB9A | |
| SCHEMBL9584018 | 0.86 | PLA2G2A (0.61) | ALDH1A1LMNA | |
| SCHEMBL9733878 | 0.85 | ALDH1A1 (0.65) | LTB4RKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-B1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5468898-A | Substituted naphthylene compounds exhibiting selective leukotriene B4 antagonist activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-11-21 | — | — | US | disclosed |
| EP-0548250-A4 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0548250-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992007829-A1 | INDOLE-3-METHANAMINES USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |
| WO-1992004321-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| US-4758586-A | Indolyl compounds and hyposensitivity use thereof | USV PHARMACEUTICAL CORP. (US) | 1988-07-19 | — | — | US | disclosed |
| EP-0189936-A2 | Hyposensitivity compounds | USV PHARMACEUTICAL CORPORATION (US) | 1986-08-06 | — | — | EP | disclosed |