Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.60 |
| ▸ | BACE1 | P56817 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | YAP1 | P46937 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6754373 | 0.84 | SIGMAR1 (0.60) | ACHEBACE1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7682403 | 0.79 | LDHA (0.56) | LDHAALDH1A1KDM4E | |
| SCHEMBL7684481 | 0.75 | SIGMAR1 (0.56) | ACHEBACE1KMT2AMEN1KDM4E | |
| SCHEMBL8245315 | 0.72 | ACHE (0.67) | ACHEKMT2AMEN1ALDH1A1 | |
| SCHEMBL25237317 | 0.72 | MEN1 (0.67) | ACHEBACE1KMT2AMEN1ALDH1A1 | |
| SCHEMBL31178381 | 0.72 | MEN1 (0.67) | ACHEBACE1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9030920 | 0.71 | ACHE (0.60) | ACHEKMT2AMEN1ALDH1A1 | |
| SCHEMBL5353463 | 0.70 | MEN1 (0.63) | KMT2AMEN1ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL9030029 | 0.70 | ACHE (0.59) | ACHEKMT2AMEN1ALDH1A1 | |
| SCHEMBL7682400 | 0.70 | LDHA (0.58) | KMT2AMEN1LDHAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492522-B1 | OPTICAL ISOMERS AND SALTS WITH 4-PYRIDINECARBOXALDEHYDE IN THE PRESENCE OF BASE TO GIVE A COMPOUND OF THE FORMULA REACTING THE COMPOUND OBTAINED IN STEP B) ABOVE OR A SALT THEREOF WITH A COMPOUND OF FORMULA R.SUP.10 X, WHEREIN R.SUP.10, | FINETECH LABORATORIES LTD. (IL) | 2002-12-10 | — | — | US | disclosed |
| EP-1129073-A2 | PROCESS AND INTERMEDIATES FOR PRODUCTION OF DONEPEZIL AND RELATED COMPOUNDS | Finetech Ltd (IL) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000009483-A2 | PROCESS AND INTERMEDIATES FOR PRODUCTION OF DONEPEZIL AND RELATED COMPOUNDS | FINETECH LTD. (IL) | 2000-02-24 | — | — | WO | disclosed |