SCHEMBL7681107

SCHEMBL7681107

CCOC(=O)c1c(CC)nc(-c2ccccc2)c(C(=O)OCC)c1C

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 17/20 0.78
NPSR1 Q6W5P4 2/20 0.56
KDM4E B2RXH2 2/20 0.56
ALDH1A1 P00352 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
NPC1 O15118 1/20 0.56
LMNA P02545 1/20 0.56
GAA P10253 1/20 0.56
MAPT P10636 1/20 0.56
HPGD P15428 1/20 0.56
RAB9A P51151 1/20 0.56
GMNN O75496 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
TMIGD3 P0DMS9 1/20 0.53
CYP2C9 P11712 1/20 0.53
TSHR P16473 1/20 0.53
NFKB1 P19838 1/20 0.53
MAPK1 P28482 1/20 0.53
ADORA2A P29274 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28199488 0.84 ADORA3 (0.76) ADORA3NPSR1KDM4EALDH1A1SMN1; SMN2
SCHEMBL6379843 0.80 ADORA3 (1.00) ADORA3NPSR1GMNNCYP1A2CYP3A4
SCHEMBL30741222 0.80 ADORA3 (1.00) ADORA3NPSR1GMNNCYP1A2CYP3A4
SCHEMBL7686721 0.80 ADORA3 (1.00) ADORA3NPSR1KDM4EALDH1A1SMN1; SMN2
SCHEMBL6439576 0.78 ADORA3 (0.86) ADORA3NPSR1GMNNCYP1A2CYP3A4
SCHEMBL7678825 0.78 ADORA3 (1.00) ADORA3NPSR1KDM4EALDH1A1SMN1; SMN2
SCHEMBL13780197 0.77 ADORA3 (0.74) ADORA3NPSR1KDM4EALDH1A1SMN1; SMN2
SCHEMBL8873390 0.77 PDE10A (0.59) ADORA3TSHR
SCHEMBL7686715 0.76 ADORA3 (0.90) ADORA3NPSR1KDM4EALDH1A1SMN1; SMN2
SCHEMBL31115715 0.76 ALDH1A1 (0.57) ADORA3NPSR1KDM4EALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US claimed
WO-2000002861-A1 A3 ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-01-20 WO claimed
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US disclosed
WO-2000002861-A1 A3 ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-01-20 WO disclosed