Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362624 | 0.86 | TDP1 (0.56) | HPGDTDP1TACR1POLBSLC6A2 | |
| SCHEMBL5230558 | 0.84 | PLA2G1B (0.45) | TDP1TACR1GAASLC6A2SLC6A4 | |
| SCHEMBL23875683 | 0.82 | LTB4R (0.52) | LTB4RLTB4R2HPGDALDH1A1FFAR1 | |
| SCHEMBL15427664 | 0.82 | KCNA5 (0.44) | LTB4RLTB4R2ALDH1A1 | |
| SCHEMBL22025118 | 0.82 | TDP1 (0.43) | TDP1TACR1GAASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL6161684 | 0.81 | TDP1 (0.42) | ALDH1A1TDP1CYP3A4TACR1GAA | |
| SCHEMBL1781861 | 0.81 | GABBR2 (0.51) | ALDH1A1TDP1TACR1POLBGAA | |
| SCHEMBL12826999 | 0.80 | AOC3 (0.41) | LTB4RLTB4R2HPGDALDH1A1TDP1 | |
| SCHEMBL13496165 | 0.80 | HDAC4 (0.40) | LTB4RLTB4R2HPGDAOC3BCHE | |
| SCHEMBL6343341 | 0.80 | EPHX1 (0.49) | ALDH1A1TDP1TACR1NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |