Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PROC | P04070 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681396 | 0.86 | AKR1B1 (0.37) | SLC7A5 | |
| SCHEMBL4061971 | 0.84 | FOLH1 (0.50) | PLA2G10PLA2G2AFOLH1F10 | |
| SCHEMBL4063724 | 0.81 | BID (0.36) | PLA2G10PLA2G2AHPGDSFOLH1 | |
| SCHEMBL4062969 | 0.80 | ADRA1D (0.36) | PLA2G10PLA2G2AFOLH1 | |
| SCHEMBL4063820 | 0.80 | KDM4E (0.37) | PLA2G10PLA2G2AHPGDSHTT | |
| SCHEMBL4061937 | 0.79 | HMGB1 (0.34) | PLA2G10PLA2G2A | |
| SCHEMBL7685992 | 0.78 | GRIA2 (0.41) | HPGDSFOLH1 | |
| SCHEMBL4066977 | 0.78 | CYP3A4 (0.36) | PLA2G10PLA2G2A | |
| SCHEMBL7679450 | 0.77 | TRPV1 (0.48) | SLC7A5 | |
| SCHEMBL4070172 | 0.76 | KMT2A (0.33) | PLA2G10PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |