Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR5 | P32302 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678090 | 0.85 | CXCR5 (0.44) | CXCR5KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL7677714 | 0.85 | CXCR5 (0.42) | CXCR5SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL7675116 | 0.83 | ALDH1A1 (0.53) | CXCR5RXRAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL27353157 | 0.80 | KMT2A (0.42) | RXRAKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL2812292 | 0.75 | ALDH1A1 (0.43) | CXCR5RXRAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3941319 | 0.75 | ACHE (0.41) | CXCR5SMN1; SMN2CDC25BKDM4EHSD17B10 | |
| SCHEMBL7394964 | 0.75 | DRD2 (0.42) | SMN1; SMN2RXRACDC25BKDM4EHSD17B10 | |
| SCHEMBL9838900 | 0.74 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL11731471 | 0.74 | AKR1C4 (0.44) | CXCR5SMN1; SMN2RXRAKDM4EHSD17B10 | |
| SCHEMBL4264371 | 0.74 | CXCR5 (0.45) | CXCR5SMN1; SMN2FABP4RXRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403601-B1 | TREATMENT OF ASTHMA, ANXIETY, DEPRESSION, EMESIS, URINARY INCONTINENCE AND RELATED CONDITIONS. | ASTRAZENECA AB (SE) | 2002-06-11 | — | — | US | disclosed |
| EP-1137637-A1 | N-(2-PHENYL-4-PIPERIDINYLBUTYL)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENECARBOXAMIDES AND THEIR USE AS NEUROKININ 1 (NK1) AND/OR NEUROKININ 2 (NK2) RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034243-A1 | N-(2-PHENYL-4-PIPERIDINYBUTYL)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENECARBOXAMIDES AND THEIR USE AS NEUROKININ 1 (NK1) AND/OR NEUROKININ 2 (NK2) RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |
| US-4011326-A | 2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents | MERCK & CO., INC. (US) | 1977-03-08 | — | — | US | disclosed |