Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7682016 | 0.93 | MAPT (0.52) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL7682013 | 0.93 | MAPT (0.52) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL12704884 | 0.90 | MAPT (0.51) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL12993689 | 0.85 | MAPT (0.54) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL13041058 | 0.84 | MAPT (0.53) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL8583137 | 0.83 | MAPT (0.51) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL9035406 | 0.83 | ALDH1A1 (0.54) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL7210375 | 0.82 | MAPT (0.52) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL11124304 | 0.82 | MAPT (0.48) | MAPTTHRBMEN1KMT2AAKR1C3 | |
| SCHEMBL9652442 | 0.82 | SMN1; SMN2 (0.48) | MAPTMEN1KMT2AAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469181-B1 | PREPARING 2-OXINDOLES AND N-HYROXY-2- OXINDOLES VIA REDUCTION OF 2-NITROARYLMALONATE DIESTERS WITHOUT ISOLATION OF INTERMEDIATES | CATALYTICA, INC. | 2002-10-22 | — | — | US | disclosed |